Facile synthesis of polymer–peptide conjugates via direct amino acid coupling chemistry |
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Authors: | Gwen F. Chimonides Arun A. Sohdi Mohammad R. Khaleghi Claire R. Hurley Dave J. Adams Paul D. Topham |
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Affiliation: | 1. Chemical Engineering and Applied Chemistry, Aston University, , Aston Triangle, Birmingham, B4 7ET United Kingdom;2. Sheffield Surface Analysis Centre, Kroto Research Institute, The University of Sheffield, , Sheffield, S3 7HQ United Kingdom;3. Department of Chemistry, University of Liverpool, , Liverpool, L69 7ZD United Kingdom |
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Abstract: | Polymer–peptide conjugates (also known as biohybrids) are attracting considerable attention as injectable materials owing to the self‐assembling behavior of the peptide and the ability to control the material properties using the polymer component. To this end, a simple method for preparing poly(ethylene oxide)‐oligophenylalanine polymer–peptide conjugates (mPEOm‐Fn‐OEt) using isobutylchloroformate as the activating reagent has been identified and developed. The synthetic approach reported employs an industrially viable route to produce conjugates with high yield and purity. Moreover, the approach allows judicious selection of the precursor building blocks to produce libraries of polymer–peptide conjugates with complete control over the molecular composition. Control over the molecular make‐up of the conjugates allows fine control of the physicochemical properties, which will be exploited in future studies into the prominent self‐assembling behavior of such materials. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013 , 51, 4853–4859 |
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Keywords: | block copolymers peptides synthesis |
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