Poly(ethylene glycol)‐crosslinked fullerenes for high efficient phototherapy |
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Authors: | Dong Jin Lee Yong Sik Ahn Yu Seok Youn Eun Seong Lee |
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Affiliation: | 1. Division of Biotechnology, The Catholic University of Korea, , Gyeonggi‐do, 420‐743 Republic of Korea;2. College of Pharmacy, SungKyunKwan University, , Jangan‐gu, Suwon, Republic of Korea |
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Abstract: | Poly(ethylene glycol)‐crosslinked multimeric C60 was developed for use in photothermal/photodynamic therapy of malignant cells. We showed that: (i) the tumor surface temperature on KB tumor‐bearing nude mice treated with multimeric C60 reached about 44 °C; (ii) this hyperthermic condition and tremendous singlet oxygen generation from multimeric C60 resulted in significant tumor volume regression in KB tumor‐bearing nude mice; and (iii) multimeric C60 also efficiently inhibited arthritic progress in the arthritis‐induced DBA/1 J mice model. This multimeric C60 may be useful for photothermal/photodynamic cell ablation in various malignant cells. Copyright © 2012 John Wiley & Sons, Ltd. |
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Keywords: | multimeric fullerene photothermal photodynamic cancer therapy rheumatoid arthritis therapy |
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