Copper(I) oxide and benzoic acid ‘on water’: a highly practical and efficient catalytic system for copper(I)-catalyzed azide-alkyne cycloaddition |
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| Authors: | Changwei ShaoRui Zhu Sheng LuoQun Zhang Xinyan Wang Yuefei Hu |
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| Institution: | Department of Chemistry, Tsinghua University, Beijing 100084, PR China |
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| Abstract: | A simple combination of Cu2O and PhCO2H ‘on H2O’ has been developed as a highly practical and efficient catalytic system for copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). It not only provides a further evidence for the strategy of carboxylic acids-promoted CuAAC, but also offers significant advantages to CuAAC because Cu2O is one of the most stable and cheapest Cu(I) sources; PhCO2H is one of the structurally simplest bidentate ligands; and water is the most ‘green’ solvent. |
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| Keywords: | Benzoic acid Copper(I) oxide Catalysis Click chemistry |
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