An enzymatic approach to the desymmetrization of disubstituted pyrrolines |
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| Authors: | Donohoe Timothy J Rigby Caroline L Thomas Rhian E Nieuwenhuys William F Bhatti Farrah L Cowley Andrew R Bhalay Gurdip Linney Ian D |
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| Institution: | Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK. timothy.donohoe@chem.ox.ac.uk |
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| Abstract: | The enzymatic desymmetrization of 2,2- and 2,5-disubstituted pyrroline compounds is reported in a procedure which gives access to both enantiomers in excellent enantiomeric excess and good yield. The enzyme reaction precursors are formed easily from two readily available substituted pyrroles using both ammonia (Na/NH3) and ammonia-free (Li/DBB) Birch reduction conditions. |
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