A [3 + 3] annelation approach to tetrahydropyridines |
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Authors: | Pattenden Lisa C Wybrow Robert A J Smith Stephen A Harrity Joseph P A |
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Affiliation: | Department of Chemistry, University of Sheffield, Brook Hill, UK. |
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Abstract: | [reaction: see text] A stepwise [3+3] annelation sequence to tetrahydropyridines via addition of the Büchi Grignard to aziridines has been developed. These intermediates can be further functionalized with good regio- and stereocontrol and this methodology has been employed in the stereoselective formal synthesis of (-)-dihydropinidine. |
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