| 有抗病毒活性的苯并咪唑苯氧乙酸乳糖酯的催化合成 |
| |
| 引用本文： | 陈洪,谢建英,黄思庆.有抗病毒活性的苯并咪唑苯氧乙酸乳糖酯的催化合成[J].化学研究与应用,2005,17(6):799-801. |
| |
| 作者姓名： | 陈洪 谢建英 黄思庆 |
| |
| 作者单位： | 广东海洋大学应化系,广东,湛江,524088;广东海洋大学应化系,广东,湛江,524088;广东海洋大学应化系,广东,湛江,524088 |
| |
| 基金项目： | 广东省教育厅自然科学基金资助课题 |
| |
| 摘 要： | 苯并咪唑及其衍生物在应用上有许多报道，是广泛使用的驱虫剂、杀真菌剂、植物病毒抑制剂、农用杀菌剂（如多菌灵），作为医药也有许多报道。芳氧羧酸类化合物是医药、农药、染料的中间体，其中一些还具有杀虫、杀菌、除草和植物激素等多方面的生物活性。
|
| 关 键 词： | 苯并咪唑苯氧乙酸乳糖酯 抗病毒活性 DMAP/Et3N |
| 文章编号： | 1005-1656（2006）06-0799-03 |
| 收稿时间： | 2005-03-04 |
| 修稿时间： | 2005-05-24 |
Catalytic synthesis of antiviral active benzimidazolyl phenoxyacetic acid lactopyranosyl saccharide carboxylate |
| |
| CHEN Hong,XIE Jian-ying,HUANG Si-qing.Catalytic synthesis of antiviral active benzimidazolyl phenoxyacetic acid lactopyranosyl saccharide carboxylate[J].Chemical Research and Application,2005,17(6):799-801. |
| |
| Authors: | CHEN Hong XIE Jian-ying HUANG Si-qing |
| |
| Institution: | Department of Applied Chemistry, Guangdong Ocean University, Zhanjiang 524088, China |
| |
| Abstract: | 4-dimethylpyridine(DMAP) was used as catalyst for preparing benzimidazolyl phenoxyacetic acid O-acetyllactopyranosyl saccharide carboxylate and triethylamine(Et_3N) was used as deacid reagent.Three saccharide carboxylates were synthesized from saccharide carboxylation at room temperature in the system of DMAP/Et_3N with nitro-containing,trifluoromethyl benzimidazolyl phenoxyacetic acid with as lead compounds.The catalytic mechanism of DMAP/Et_3N was discussed.The results showed that DMAP is a effective catalyst.The yields can reach over 52.7%.The test indicated that the compounds showed better antiviral activity against tobacco mosaie virus(TMV). |
| |
| Keywords: | benzimidazolyl phenoyacetic acid O - acetyllactopyranosyl saccharide carboxylate TMV DMAP/Et3N |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
