Preparation and spectral investigation on inclusion complex of beta-cyclodextrin with rutin |
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| Authors: | Haiyun Ding Jianbin Chao Guomei Zhang Shaomin Shuang Jinhao Pan |
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| Institution: | Department of Chemistry, Shanxi University, Taiyuan 030006, China. |
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| Abstract: | Solid inclusion complex of rutin with beta-cyclodextrin (beta-CD) was prepared by coprecipitate method. The formation of inclusion complex was confirmed by differential scanning calorimetry (DSC) and X-ray diffraction. The formation constant was obtained by steady-state fluorescence measurements and the result suggested the complex preferred 1:1 (rutin:CD) stoichiometry. Furthermore, the spatial configuration of the complex has been proposed based on NMR and molecular modeling. |
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| Keywords: | β -Cyclodextrin Rutin Fluorescence Nuclear magnetic resonance |
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