Generation of acyl anion equivalents from acylphosphonates via phosphonate-phosphate rearrangement: a highly practical method for cross-benzoin reaction |
| |
| Authors: | Demir Ayhan S Reis Omer Iğdir A Ciğdem Esiringü Ilker Eymur Serkan |
| |
| Institution: | Deparment of Chemistry, Middle East Technical University, 06531 Ankara, Turkey. asdemir@metu.edu.tr |
| |
| Abstract: | reactions: see text] Acylphosphonates are potent acyl anion precursors that generate acyl anion equivalents under the promotion of cyanide anion via phosphonate-phosphate rearrangement. These anions readily react with aldehydes to provide cross-benzoin products. In this way it is possible to synthesize a variety of aromatic-aromatic, aromatic-aliphatic, and aliphatic-aromatic benzoins. Moreover the reaction of benzoylphosphonate with potent electrophile 2,2,2-trifluoroacetophenone provided the corresponding aldehyde-ketone coupling product in high yield. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
