| 脑益嗪对受前庭刺激家兔的脑血流图功率谱和眼震颤的影响 |
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| 引用本文： | 朱俐,庄坚,高静,吴娟,张祖暄.脑益嗪对受前庭刺激家兔的脑血流图功率谱和眼震颤的影响[J].南京大学学报(自然科学版),1997,33(3):459-463. |
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| 作者姓名： | 朱俐 庄坚 高静 吴娟 张祖暄 |
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| 作者单位： | 南京大学医学院，南通医学院 |
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| 摘 要： | 研究了脑益嗪对受前庭刺激家兔的脑血流图功率谱和眼震颤的影响。脑血流图功率谱的计算机分析表明，有效的前庭刺激可以引起脑血管的紧张，而脑益嗪能够改善前庭刺激下的脑血流状况，并且降低旋转后眼震颤的频率和慢相速度。脑益嗪的药效作用可持续３ｈ，其作用峰值可能在２．５ｈ。实验结果提示：当前庭受过度刺激时脑益嗪可能通过扩张病理收缩状态的脑血管来对抗运动病的发生，同时也不排除其降低前庭器官敏感性的作用。
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| 关 键 词： | 脑益嗪，运动病，脑血流图功率谱，眼震颤，前庭刺激脑益嗪，运动病，脑血流图功率谱，眼震颤，前庭刺激 |
EFFECTS OF CINNARIZINE ON REG POWER SPECTRUM AND NYSTAGMUS OF RABBITS DURING THE VESTIBULAR STIMULATION |
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| Zhu Li,Zhuang Jian,Gao Jing,Wu Juan,Zhang Zuxuan.EFFECTS OF CINNARIZINE ON REG POWER SPECTRUM AND NYSTAGMUS OF RABBITS DURING THE VESTIBULAR STIMULATION[J].Journal of Nanjing University: Nat Sci Ed,1997,33(3):459-463. |
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| Authors: | Zhu Li Zhuang Jian Gao Jing Wu Juan Zhang Zuxuan |
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| Institution: | Zhu Li 1) Zhuang Jian 2) Gao Jing 1) Wu Juan 1) Zhang Zuxuan 1) |
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| Abstract: | Effects of cinnarizine on the REG power spectrum and nystagmus of rabbits during rotatory stimulation were studied. Effective vestibular stimulation might cause the tension of brain blood vessels. Cinnarizine could improve the brain blood flow during the vestibular stimulation and also reduce the frequency and velocity of slow phase of post rotatory nystagmus. The persistent period of cinnarizine would last 3.0 hours and the peak time might be at 2.5 hour. These results suggested that the protective effect of cinnarizine on motion sickness should result from a dilatation of the brain blood vessels under pathological contraction caused by vestibular stimulation and do not do away with the reduction of the sensitivity of vestibular organs. |
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| Keywords: | cinnarizine motion sickness REG power spectrum nystagmus vestibular stimulation |
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