| THE COURSE OF THE POLYPEPTIDE CHAIN OF TRICHOSANTHIN MOLECULE |
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| 作者姓名： | 潘克桢 张永茂 林玉娟 吴兹武 郑安 陈元柱 董贻诚 马星奇 王耀萍 吴伸 张明安 陈世芝 夏宗芗 田庚元 倪朝周 范肇昌 马益林 孙孝先 |
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| 作者单位： | Fujian Institute of Research on the Structure of Matter，Academia Sinica，Fuzhou，Fujian Institute of Research on the Structure of Matter，Academia Sinica，Fuzhou，Fujian Institute of Research on the Structure of Matter，Academia Sinica，Fuzhou，Fujian Institute of Research on the Structure of Matter，Academia Sinica，Fuzhou，Fujian Institute of Research on the Structure of Matter，Academia Sinica，Fuzhou，Fujian Institute of Research on the Structure of Matter，Academia Sinica，Fuzhou，Institute of Biophysics，Academia Sinica，Beijing，Institute of Biophysics，Academia Sinica，Beijing，Institute of Biophysics，Academia Sinica，Beijing，Institute of Biophysics，Academia Sinica，Beijing，Institute of Biophysics，Academia Sinica，Beijing，Institute of Biophysics，Academia Sinica，Beijing，Shanghai Institute of Organic Chemistry，Academia Sinica，Shanghai Institute of Organic Chemistry，Academia Sinica，Shanghai Institute of Organic Chemistry，Academia Sinica，Shanghai Institute of Organic Chemistry，Academia Sinica，Shanghai Institute of Organic Chemistry，Academia Sinica，Shanghai Institute of Organic Chemistry，Academia Sinica |
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| 摘 要： | The course of the polypeptide chain of Trichosanthin has been determined from the electron density map at 4 resolution. The structure belongs to α+β type. It contains eight α-helices (39% of total residues) and four β-sheets (32% of total residues) which are made up of thirteen β-strands. The α-helices are relatively in the centre of the molecule and surrounded by β-sheets. This is the characteristic feature of Trichosanthin structure. This kind of structural arrangement has not been reported before. The transformation matrix and translation vector, which superpose two molecules in one asymmetric unit, were obtained. The root mean square error is 1.31 for this superposition.
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