Palladium-catalyzed borylation of phenyl bromides and application in one-pot Suzuki-Miyaura biphenyl synthesis |
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Authors: | Broutin Pierre-Emmanuel Cerna Igor Campaniello Maria Leroux Frédéric Colobert Françoise |
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Affiliation: | Laboratoire de Stéréochimie associé au CNRS (UMR 7008), Université Louis Pasteur (ECPM), 25 rue Becquerel, F-67087 Strasbourg Cedex 2, France. |
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Abstract: | The coupling reaction of pinacolborane with various aryl bromides in the presence of a catalytic amount of Pd(OAc)(2) together with DPEphos as ligand and Et(3)N as base provided arylboronates. High yields were obtained in the case of electron-donor substituted aryl bromides. The direct preparation of arylboronates allowed the one-pot, two-step synthesis of unsymmetrical biaryls in high yields. [reaction: see text] |
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