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Pluronic F-68 nanodots incorporating pyrimidine chromophores |
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| Authors: | Laeticia Vurth Caroline Hadad Sylvain Achelle Joaquín C García-Martinez Julián Rodríguez-López Olivier Stéphan |
| Institution: | 1. Laboratoire Interdisciplinaire de Physique, CNRS UMR 5588, Université Grenoble 1, Grenoble, 38402, France 2. Facultad de Química, Universidad de Castilla-La Mancha, 13071, Ciudad Real, Spain 3. Sciences Chimiques de Rennes, UMR CNRS 6226, IUT Lannion, B.P. 30219, Rue E. Branly, 22302, Lannion, France |
| Abstract: | We report the synthesis of nanosized particles based on bio-compatible polyethylene–polypropylene glycol (pluronic) materials. In aqueous solution, mini-emulsification of pluronic with two pyrimidine chromophores leads to nanoparticles with hydrodynamic radius below 100?nm. We have demonstrated that these probes exhibit a fast and fully reversible solvatochromic behaviour from yellow to purple when decreasing the pH solution. The average acidity constant of both dyes incorporated in pluronic mainly originate from the non-substituted pyrimidine (1,3-diazine) core. The close functionalization of the pyrimidine with pyridyl groups leads to a tridentate ligand suitable for metal cations complexation. Aqueous nanoparticles of pluronic triblock copolymer incorporating pyrimidine chromophores are sensitive to pH changes: protonation of the dyes within the micelles core occurs in strong acidic aqueous media leading to purple coloration when compared to yellow colour in neutral or basic pH. This solvatochromic behaviour is fully reversible. |
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