High-resolution NMR spectroscopy of a GPCR in aligned bicelles |
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| Authors: | Park Sang Ho Prytulla Stefan De Angelis Anna A Brown Jonathan Miles Kiefer Hans Opella Stanley J |
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| Institution: | Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0307, USA. |
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| Abstract: | Solid-state NMR spectra with single-site resolution of CXCR1, a G protein-coupled receptor (GPCR), were obtained in magnetically aligned phospholipid bicelles. These results demonstrate that GPCRs in phospholipid bilayers are suitable samples for structure determination by solid-state NMR. The spectra also enable studies of drug-receptor interactions. |
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