拉曼光谱在固相有机合成中的应用

本文综述了近几年以来拉曼光谱在固相有机合成中的应用研究进展，分别介绍了近红外傅立叶变换和共焦显微两种拉曼光谱技术。近红外傅立叶变换拉曼光谱克服了荧光背景带来的干扰，可以用在固载试剂、催化剂的表征、固相有机反应的监测等方面，特别对于在无机载体上进行的有机反应的表征和检测方面具有很大的优势。共焦显微拉曼光谱具有特殊的空间分辨能力，适合对固相合成载体的结构进行表征，并可对载体内部反应活性位点的分布情况进行研究。

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The recent application of Baman spectroscopy in solid-phase organic synthesis is reviewed. Two Baman spectra techniques of NIR-FT-Baman spectroscopy and confocal Baman microscopy are introduced respectively. NIR-FT- Raman spectroscopy can be used for the characterization of solid-supported reagents and catalysts, for monitoring the solid-phase reactions, and especially for monitoring the solid-phase reactions on inorganic supports since the interference of fluorescence emission background can be removed by this technique. Confocal Baman microscopy is used to study the distribution of reactive sites within a resin bead and characterize the structure of grafted supports used for solid-phase synthesis taking the advantage of its high spatial resolution.