| Synthesis of N-Phosphoryl Branched Peptides |
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| 引用本文： | ShengLiCAO HuaFU YuFenZHAO. Synthesis of N-Phosphoryl Branched Peptides[J]. 中国化学快报, 2005, 16(3): 317-320 |
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| 作者姓名： | ShengLiCAO HuaFU YuFenZHAO |
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| 作者单位： | [1]DepartmentofChemistry,Capital-NormalUniversity,Beijing100037 [3]TheKeyLaboratoryofBioorganicPhosphorusChemistry,MinistryofEducation;DepartmentofChemistry,TsinghuaUniversity,Beijing100084 |
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| 摘 要： | H-phosphonates were conveniently prepared by direct transesterification of diphenyl phosphite (DPP) with the corresponding alcohols, without further purification they were reacted with branched peptide methyl ester (L-Leu2-L-LysOMe) through Atherton-Todd method, a series of different substituted alkyloxy (N-phosphoryl-L-Leu)2-L-LysOMe were synthesized, and their stmctures were confirmed by ^31P NMR, ESI-MS, ^1H NMR, ^13C NMR, IR and elemental analysis. The approach possesses the advantages of easy operation, high yield and inexpensive phosphorylating reagent.
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| 关 键 词： | 合成 N-磷酰基支链肽 H-膦酸酯 Atherton-Todd反应 酯交换反应 |
Synthesis of N-Phosphoryl Branched Peptides |
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| Jie YANG,,Yu Yang JIANG,,Sheng Li CAO,Hua FU,Yu Fen ZHAO The Key Laboratory of Bioorganic Phosphorus Chemistry,Ministry of Education. Synthesis of N-Phosphoryl Branched Peptides[J]. Chinese Chemical Letters, 2005, 16(3): 317-320 |
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| Authors: | Jie YANG Yu Yang JIANG Sheng Li CAO Hua FU Yu Fen ZHAO The Key Laboratory of Bioorganic Phosphorus Chemistry Ministry of Education |
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| Affiliation: | Jie YANG1,2,Yu Yang JIANG1,2*,Sheng Li CAO3,Hua FU1,Yu Fen ZHAO1 1 The Key Laboratory of Bioorganic Phosphorus Chemistry,Ministry of Education, Department of Chemistry,Tsinghua University,Beijing 100084 2The Key Laboratory of Chemical Biology,Guangdong Province,Graduate School at Shenzhen,Tsinghua University,Shenzhen 518055 3Department of Chemistry,Capital Normal University,Beijing 100037 |
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| Abstract: | H-phosphonates were conveniently prepared by direct transesterification of diphenyl phosphite (DPP) with the corresponding alcohols, without further purification they were reacted with branched peptide methyl ester (L-Leu2-L-LysOMe) through Atherton-Todd method, a series of different substituted alkyloxy (N-phosphoryl-L-Leu)2-L-LvsOMe were synthesized, and their structures were confirmed by P NMR, ESI-MS, H NMR,13 C NMR, IR and elemental analysis. 31 1 The approach possesses the advantages of easy operation, high yield and inexpensive phosphorylating reagent. |
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| Keywords: | N-Phosphoryl branched peptide H-phosphonate Atherton-Todd reaction transesterification. |
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