Solvatomorphism of Moxidectin |
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| Authors: | Toni Grell Mauro Barbero Franco Pattarino Giovanni Battista Giovenzana Valentina Colombo |
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| Affiliation: | 1.Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, I-20133 Milano, Italy;2.Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale A. Avogadro, Largo Donegani 2/3, I-28100 Novara, Italy; (M.B.); (F.P.); (G.B.G.) |
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| Abstract: | The solvatomorphism of the anthelmintic drug moxidectin is investigated, and a new solvatomorph with nitromethane is reported. Moreover, the hitherto unknown crystal structures of the solvatomorphs with ethanol and 2-propanol are reported and discussed. The thermal characterization of these solvatomorphs through variable-temperature powder X-ray diffraction analysis (VT-PXRD) is also described, providing new insights into the crystallochemistry of this active pharmaceutical ingredient. |
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| Keywords: | moxidectin solvatomorphism X-ray diffraction variable-temperature PXRD |
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