Influence of Dietary Chitosan Feeding Duration on Glucose and Lipid Metabolism in a Diabetic Rat Model |
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Authors: | Shing-Hwa Liu Shih-An Feng Chen-Yuan Chiu Meng-Tsan Chiang |
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Institution: | 1.Graduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan;2.Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan;3.Department of Pediatrics, College of Medicine, National Taiwan University Hospital, Taipei 10051, Taiwan;4.Department of Food Science, National Taiwan Ocean University, Keelung 20224, Taiwan;5.Center of Consultation, Center for Drug Evaluation, Taipei 115, Taiwan; |
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Abstract: | This study was designed to investigate the influence of dietary chitosan feeding-duration on glucose and lipid metabolism in diabetic rats induced by streptozotocin and nicotinamide a non-insulin-dependent diabetes mellitus (NIDDM) model]. Male Sprague-Dawley rats were used as experimental animals and divided into short-term (6 weeks) and long-term (11 weeks) feeding durations, and each duration contained five groups: (1) control, (2) control + 5% chitosan, (3) diabetes, (4) diabetes + 0.8 mg/kg rosiglitazone (a positive control), and (5) diabetes + 5% chitosan. Whether the chitosan feeding was for 6 or 11 weeks, the chitosan supplementation decreased blood glucose and lipids levels and liver lipid accumulation. However, chitosan supplementation decreased plasma tumor necrosis factor (TNF)-α, insulin levels, alanine aminotransferase (ALT) activity, insulin resistance (HOMA-IR), and adipose tissue lipoprotein lipase activity. Meanwhile, it increased plasma high-density lipoproteins (HDL)-cholesterol level, plasma angiopoietin-like-4 protein expression, and plasma triglyceride levels (at 11-week feeding duration only). Taken together, 11-week (long-term) chitosan feeding may help to ameliorate the glucose and lipid metabolism in a NIDDM diabetic rat model. |
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Keywords: | chitosan diabetes glucose and lipid metabolism |
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