|
|||||
|
|
Prenylated Flavonoids and C-15 Isoprenoid Analogues with Antibacterial Properties from the Whole Plant of Imperata cylindrica (L.) Raeusch (Gramineae) |
|
| Authors: | Romeo D. Tadjouate Nago Paul Nayim Armelle T. Mbaveng James D. Simo Mpetga Gabin T. Mbahbou Bitchagno Badawe Garandi Pierre Tane Bruno N. Lenta Norbert Sewald Mathieu Tene Victor Kuete Augustin Silvere Ngouela |
| Affiliation: | 1.Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Cameroon; (R.D.T.N.); (M.T.); (A.S.N.);2.Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Cameroon; (P.N.); (A.T.M.); (B.G.); (V.K.);3.Organic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany;4.Department of Chemistry, Higher Teacher Training College, University of Yaounde I, P.O. Box 47 Yaounde, Cameroon; |
| Abstract: | The local botanical Imperata cylindrica in Cameroon was investigated for its antibacterial potency. The methanol extract afforded a total of seven compounds, including five hitherto unreported compounds comprising three flavonoids (1–3) and two C-15 isoprenoid analogues (4 and 5) together with known derivatives (6 and 7). The novelty of the flavonoids was related to the presence of both methyl and prenyl groups. The potential origin of the methyl in the flavonoids is discussed, as well as the chemophenetic significance of our findings. Isolation was performed over repeated silica gel and Sephadex LH-20 column chromatography and the structures were elucidated by (NMR and MS). The crude methanol extract and isolated compounds showed considerable antibacterial potency against a panel of multi-drug resistant (MDR) bacterial strains. The best MIC values were obtained with compound (2) against S. aureus ATCC 25923 (32 µg/mL) and MRSA1 (16 µg/mL). |
| Keywords: | Imperata cylindrica Gramineae flavonoids terpenoids antibacterial properties |