| IgA肾病免疫吸附剂的研究(Ⅰ) |
| |
| 引用本文： | 褚佳强,陈建军,孔德领,俞耀庭,朱伯儒,刘景铎.IgA肾病免疫吸附剂的研究(Ⅰ)[J].离子交换与吸附,2002,18(4):369-373. |
| |
| 作者姓名： | 褚佳强 陈建军 孔德领 俞耀庭 朱伯儒 刘景铎 |
| |
| 作者单位： | 1. 教育部生物活性材料重点实验室,南开大学,天津,300071
2. 北京空军总医院,北京,100036 |
| |
| 基金项目： | 国家自然科学基金 (No.: 59703006) |
| |
| 摘 要： | 本文采用碳酰二咪唑（N，N'-Carbonyldiimidazole,CDI)为活化剂^1]，活化琼脂糖载体，并以人免疫球蛋白G（IgG)，为配基制成的免疫吸附剂首次探讨了对高IgA肾病病人血清进行体外清除IgA的实验，吸附率为30－35％，具有一定的清除效果。
|
| 关 键 词： | 免疫吸附剂 IgG配基 IgA肾病 琼脂糖 治疗 碳酰二咪唑 载体 活化剂 |
| 文章编号： | 1001-5493(2002)04-0369-05 |
| 修稿时间： | 2001年12月22 |
IN VITRO STUDIES OF THE IMMUNOADSORBENT FOR REMOVAL OF IgA IN IGA-NEPHROPATHY (I) |
| |
| CHEN Jianjun CHU Jiaqiang KONG Deling YU Yaoting ZHU Boru LIU Jingduo State Key Lab of Bioactive Materials Research,Nankai University,Tianjin Air Force Military General Hospital,Beijng.IN VITRO STUDIES OF THE IMMUNOADSORBENT FOR REMOVAL OF IgA IN IGA-NEPHROPATHY (I)[J].Ion Exchange and Adsorption,2002,18(4):369-373. |
| |
| Authors: | CHEN Jianjun CHU Jiaqiang KONG Deling YU Yaoting ZHU Boru LIU Jingduo State Key Lab of Bioactive Materials Research Nankai University Tianjin Air Force Military General Hospital Beijng |
| |
| Institution: | CHEN Jianjun1 CHU Jiaqiang1 KONG Deling1 YU Yaoting1 ZHU Boru1 LIU Jingduo2 1 State Key Lab of Bioactive Materials Research,Nankai University,Tianjin 300071 2 Air Force Military General Hospital,Beijng 100036 |
| |
| Abstract: | Immunoadsorbent for the removal of IgA from serum of patients was prepared by using CDI(N,N'-Carbonyldiimidazole) as activator, agarose as carrier and human immunoglobulin G(IgG) as ligand. Various factors influencing the adsorption of IgA were studied and optimized. The immunoadsorbent thus prepared can adsorb IgA to 30~35% in vitro experiments. |
| |
| Keywords: | Immunoadsorbent IgG ligand IgA-nephropathy Agarose |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
