|
|||||
|
|
Oligoribonucleotides containing an aminoalkyl group at the N(4) atom of cytosine as precursors of new reagents for site-specific modifications of biopolymers |
|
| Authors: | M N Repkova M I Meshchaninova T M Ivanova N I Komarova D V Pyshnyi A G Venyaminova |
| Institution: | (1) Novosibirsk Institute of Bioorganic Chemistry, 8 prosp. Akad. Lavrent"eva, 630090 Novosibirsk, Russian Federation |
| Abstract: | A solid-phase H-phosphonate procedure was developed for the synthesis of oligoribonucleotides containing aliphatic amino linkers with different lengths at the N(4) atom of cytosine. The hybridization properties of modified oligoribonucleotides were studied. Thermal stability of the RNA—RNA* and DNA—RNA* duplexes depends on the position of modified cytosine in the chain and the type of the duplex. |
| Keywords: | oligoribonucleotides H-phosphonate synthesis modification cytosine aliphatic amino linkers duplex stability |
| 本文献已被 SpringerLink 等数据库收录！ | |