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A Stochastic Model for Wound Healing
Authors:Thomas Callaghan  Evgeniy Khain  Leonard M Sander  Robert M Ziff
Institution:(1) School of Mathematics, Georgia Institute of Technology, Georgia, USA;(2) Michigan Center for Theoretical Physics, Michigan, USA;(3) Department of Physics, University of Michigan, Michigan, USA;(4) Department of Chemical Engineering, University of Michigan, Michigan, USA
Abstract:We present a discrete stochastic model which represents many of the salient features of the biological process of wound healing. The model describes fronts of cells invading a wound. We have numerical results in one and two dimensions. In one dimension we can give analytic results for the front speed as a power series expansion in a parameter, p, that gives the relative size of proliferation and diffusion processes for the invading cells. In two dimensions the model becomes the Eden model for p ≈ 1. In both one and two dimensions for small p, front propagation for this model should approach that of the Fisher-Kolmogorov equation. However, as in other cases, this discrete model approaches Fisher-Kolmogorov behavior slowly.
Keywords:front propagation  wound healing  stochastic modeling  Fisher-Kolmogorov equation
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