Synthesis of certain 5-substituted thieno[2,3-b]thiophene-2-sulfonamides and thieno[2,3-b]thiophene-2-sulfonamide 6,6-dioxides |
| |
Authors: | Hwang-Hsing Chen Jesse A May Vincent M Lynch |
| |
Abstract: | A series of the title compounds were prepared for evaluation as inhibitors of carbonic anhydrase II. Oxidation of 5-substituted thieno2,3-b]thiophene-2-sulfonamides provided the first examples of thiophene2,3-b]thiophene-2-sulfonarnide 6,6-dioxides. These cyclic vinyl sulfones readily underwent addi tion to give predominately that 4,5-cis addition product. |
| |
Keywords: | |
|
|