9,9′-Thiobis-(1,2,3,4,7,8-hexahydro-7-methyl-6H-pyrimido[1,6-a]pyrimidine-6,8-dione) |
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Authors: | Ondrej imo Alfonz Rybr Juraj Alfldi Vladimír Ptoprstý |
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Institution: | Ondrej Šimo,Alfonz Rybár,Juraj Alföldi,Vladimír Pätoprstý |
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Abstract: | The 6-(3-hydroxypropylamino)-3-methylpyrimidine-2,4-dione (1) did not afford the expected 6-(3-chloro-propylamino)- derivative on reaction with thionyl chloride, but, instead, the pyrimidine rings were joined via a sulfur bridge to give 9,9′-thiobis(1,2,3,4,7,8-hexahydro-7-melnyl-6H-pyrimido1,6-a]pyrirnidine-6,8-dione) ( 3 ). An identical 9,9′-thiobis- derivative 3 was obtained when reacting thionyl chloride with 1,2,3,4,7,8-hexahydro-7-methyl-6H-pyrimido1,6-a]pyrimidine-6,8-dione ( 4 ). We suppose the sulfoxide- derivative 2 to be the intermediate of both routes: it underwent reduction to the final sulfide 3 in excess thionyl chloride. |
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