Synthesis of 2(3H)-benzoxazolinone derivatives as potential beta-3-adrenergic receptor ligands

Beta-3-subtype-adrenoceptors mediate lipolysis and in the search for potential beta-3-adrenergic receptor agonists for the treatment of obesity, we designed new arylethanolamines, structures B₁ and B₂, derived from 2(3H)-benzoxazolinone. To obtain these target compounds as starting materials, various N-benzyl-2(3H)-benzoxazolinon-6-yl]ethylamines were used.