Synthesis of new 6-Aroylpyrido[2,3-d]pyrimidines |
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Authors: | Jairo Quiroga GermN Viveros Braulio Insuasty Manuel Nogueras Adolfo Snchez Justo Cobo |
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Institution: | Jairo Quiroga,GermÁN Viveros,Braulio Insuasty,Manuel Nogueras,Adolfo Sánchez,Justo Cobo |
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Abstract: | The synthesis of 6-dimethylaminomethylenaminopyrimidin-4(3H)-ones 2 and its reaction with β-dimethyl-aminopropiophenone hydrochloride 3 is discussed in this work. The reaction of 6-aminopyrimidin-4(3H)-ones 1 with an excess of dimethylformamide dimethyl acetal gives rise to the formation of 6-dimethylaminomethyleneaminopyrimidines 2. The heating of equimolecular quantities of 2 and 3 in dimethylformamide leads to the 6-aroylpyrido2,3-d]pyrimidines derivatives 4. The structures of compounds 2 and 4 were determined on the basis of nmr measurements. |
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