Synthesis and antiviral evaluation of several 6-(Methylene-carbomethoxy)pteridine-4,7(3H,8H)-diones

The reactions of 5,6-diaminopyrimidin-4(3H)-one derivatives 1a-h , with dimethyl acetylenedicarboxylate are discussed in this paper. 6-Amino-5-(E)(1′,2′-dicarbomethoxyvinyl)aminopyrimidines, 2 , and 6-(methylenecarbomethoxy)pteridinones, 3 , have been obtained as main the products, which can be explained on the basis of a Michael addition on pyrimidine derivatives, and cyclization. Those compounds were evaluated for their in vitro antiviral activity.