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Reaction of 4-Aryl-3-thiosemicarbazides with Phenylisothiocyanate: A Facile Synthesis of Thiazole,Pyrazole and Pyrimidine Derivatives |
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| Authors: | Wagnat W. Wardakhan Daisy H. Fleita Rafat M. Mohareb |
| Abstract: | The reaction of 4-aryl-3-thiosemicarbazides 1a-d with phenylisothiocyanate gave the intermediate potasium salts 2a-d . The latter afforded 3a-d, 13a-d and 19 upon the reaction with phenacyl bromide, monochloroacetic acid and ethyl bromocyanoacetate respectively. |
| Keywords: | Thiosemicarbazides Thiazole Pyrazole Pyrimidines |