Synthesis of 5-cyanopyrazolo[3,4-b]pyridines in the reaction of 5-amino-3-methyl-1-phenylpyrazole with arylidene derivatives of malonodinitrile and ethyl cyanoacetate |
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Authors: | Jairo Quiroga,Mario Alvarado,Braulio Insuasty,Rodolfo Moreno,Enrique Ravi a,Isabel Estevez,Regina H. De Almeida S. |
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Affiliation: | Jairo Quiroga,Mario Alvarado,Braulio Insuasty,Rodolfo Moreno,Enrique Raviña,Isabel Estevez,Regina H. De Almeida S. |
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Abstract: | This paper describes the synthesis of a new series of 6-amino-4-aryl-5-cyanopyrazolo[3,4-b]pyridines 4 and 4-aryl-5-cyano-6H-pyrazolo[3,4-b]pyridin-6-ones 5 from the reaction of 5-amino-3-methyl-1-phenylpyrazole 1 with arylidene derivatives of malonodinitrile 2 and ethyl cyanoacetate 3 . The structure of the final compounds was determined on the basis of nmr measurements, especially by 1H, 1H-, 1H, 13C-COSY, DEPT and X-ray diffraction. |
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