Kinetic resolution of ketone cyanohydrin acetates with a microbial enzyme期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Kinetic resolution of ketone cyanohydrin acetates with a microbial enzyme

Authors:	Hiromichi Ohta Yoichi Kimura and Yasushi Sugano

Institution:	Department of Chemistry, Faculty of Science and Technology, Keio University Hiyoshi 3-14-1, Kohoku-ku, Yokahama 223, Japan

Abstract:	Incubation of d1-1-cyano-1-methylalkyl (or alkenyl) acetates (methyl ketone cyanohydrin acetates) with cells of IAM 4682 afforded optically active acetates and the corresponding ketones via asymmetric hydrolysis. Resulting (S)-2-cyano-2-undecyl acetate was converted to the aminofuranone derivative without losing its optical purity.

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