| Aβ蛋白分泌酶抑制剂研究进展 |
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| 引用本文： | 冯松,何煦昌,白东鲁. Aβ蛋白分泌酶抑制剂研究进展[J]. 化学进展, 2004, 16(5): 791 |
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| 作者姓名： | 冯松 何煦昌 白东鲁 |
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| 作者单位： | (中国科学院上海生命科学研究院上海药物研究所 上海 201203) |
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| 摘 要： | Aβ蛋白是淀粉样前体蛋白的代谢产物,它在脑组织中含量的异常增加可能是诱发AD的主要因素.应用分泌酶抑制剂可有效减少Aβ的生成,缓解患者症状.本文综述了其中的β分泌酶抑制剂的研究进展.
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| 关 键 词： | Aβ蛋白 β分泌酶 抑制剂 AD |
| 收稿时间： | 2003-07-01 |
| 修稿时间： | 2003-09-01 |
Studies of Secretase Inhibitors of Amyloid-β Protein |
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| Feng Song,He Xuchang,Bai Donglu. Studies of Secretase Inhibitors of Amyloid-β Protein[J]. Progress in Chemistry, 2004, 16(5): 791 |
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| Authors: | Feng Song He Xuchang Bai Donglu |
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| Affiliation: | (Shanghai Institutes for Biological Sciences, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China) |
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| Abstract: | The accumulation of the β-amyloid protein (Aβ)in the brain is the central event leading to the develop-ment of Alzheimer's disease (AD) . Aβ are 40/42-residue fragment of the brain transmembrane protein β-amyloid pre-cursor protein (APP) , released by two proteases known as the β-and 7-secreases.β-secrease has been regarded as a pri-mary drug discovery target for AD therapy. The current understanding and recent progress in the design of inhibitors of this protease are discussed. |
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| Keywords: | A&beta &beta secretase inhibitors AD |
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