An expeditious approach toward the total synthesis of CP-263,114 |
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| Authors: | Njardarson J T McDonald I M Spiegel D A Inoue M Wood J L |
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| Institution: | Sterling Chemistry Laboratory, Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, USA. |
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| Abstract: | reaction: see text] Assembly of the carbocyclic core of CP-263,114 has been accomplished efficiently and in high yield. Key steps include a phenolic oxidation/intramolecular Diels-Alder sequence, tandem radical cyclization, and the late-stage fragmentation of a densely functionalized isotwistane skeleton. |
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