Intramolecular cyclopropanation of glycals: studies toward the synthesis of canadensolide, sporothriolide, and xylobovide |
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Authors: | Yu M Lynch V Pagenkopf B L |
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Institution: | Department of Chemistry and Biochemistry, The University of Texas at Austin, 78712, USA. |
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Abstract: | reaction: see text] The first examples of copper-catalyzed intramolecular cyclopropanations of glycal-derived diazoacetates are reported. The new cyclopropanes are converted into advanced intermediates for the synthesis of bislactone natural products. Synthetic highlights include the selective monodeprotection of a di-tert-butylsilylene ether and a zinc-mediated ring opening cascade reaction. |
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