Evaluation of hydrogen bonding complementarity between a secondary sulfonamide and an alpha-amino acid residue |
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| Authors: | Langenhan J M Fisk J D Gellman S H |
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| Institution: | Department of Chemistry and Graduate Program in Biophysics, University of Wisconsin, Madison, WI 53706, USA. |
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| Abstract: | structure: see text] We report an initial step toward the development of sulfonamide-based complements for extended peptide strands. A molecule containing one secondary sulfonamide unit and one valine residue linked by a turn-forming segment was found by IR and NMR to exhibit a doubly hydrogen-bonded folding pattern in chloroform. |
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