Nucleic acid hydration: a volumetric perspective |
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| Institution: | 1. Department of Chemistry, Shahid Bahonar University of Kerman, Kerman, Iran;2. Young Researchers and Elite Club, Kerman Branch, Islamic Azad University, Kerman, Iran;1. Institute of Condensed Matter and Nanosciences (IMCN), BSMA – Croix du Sud 1 bte L7.04.01, B-1348 Louvain-la-Neuve, Belgium;2. Surface and Interface Engineered Materials, Department of Metallurgy and Materials Engineering (MTM), KU Leuven, Kasteelpark Arenberg 44, Box 2450, B-3001 Heverlee, Belgium;3. KU Leuven Centre for Surface Chemistry and Catalysis, Kasteelpark Arenberg 23, Box 2461, B-3001 Heverlee, Belgium;1. Department of Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur 721302, West Bengal, India;2. Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721302, West Bengal, India;1. Institute for Protein Research, Osaka University, 3-2, Yamadaoka, Suita, Osaka 565-0871, Japan;2. Technology Research Association for Next Generation Natural Products Chemistry, 2-3-26 Aomi, Koto-ku, Tokyo 135-0064, Japan;1. Bashkir State University, Department of Chemistry, Chair of Physical Chemistry and Chemical Ecology, 32 Zaki Validi Str., Ufa 450074, Russia;2. Ufa Institute of Chemistry, Russian Academy of Sciences, Laboratory of Chemical Physics, 69 Prospekt Oktyabrya, Ufa 450054, Russia;3. Institute of Petroleum Refining and Petrochemistry, Laboratory of Quantum Chemistry and Molecular Dynamics of the Department of Chemistry and Technology, 12 Initsiativnaya Str., Ufa 450065, Republic of Bashkortostan, Russia |
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| Abstract: | Hydration represents a major force governing the conformational preferences and drug binding properties of nucleic acids. Volumetric measurements have proven useful in characterizing the hydration properties of nucleic acid structures and their complexes with other molecules. In this paper, we present an overview of recent developments in the field of volumetric investigations of nucleic acids. We discuss, in particular, the volumetric properties of nucleic acids, their molecular components and analogs, conformational transitions of DNA and RNA, and drug–DNA interactions. We emphasize the importance of hydration as a major contributor to the energetics of molecular recognition. We also emphasize the need of expanding the field of volumetric characterizations of nucleic acid structures in an effort to gain further insight into the molecular origins of various nucleic acid recognition processes, including helix-to-coil and helix-to-helix conformational transitions, as well as drug–DNA and protein–DNA interactions. |
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