测定盐酸西布曲明的电位传感器的研制与应用

以四苯硼酸钠与盐酸西布曲明生成的离子缔合物为电活性物质,研制了盐酸西布曲明传感器。试验表明:盐酸西布曲明聚氯乙烯(PVC)膜传感器对盐酸西布曲明具有良好的选择性和电位响应特性。在pH 5的溶液中,电极电位呈现近能斯特响应,线性范围为1.0×10-6～1.0×10-1mol.L-1,斜率为50 mV.pc-1(26℃),检出限(3S/N)为5.62×10-7mol.L-1。将电极用于药物中盐酸西布曲明含量的测定,测得回收率为97.3%～100.2%,测定值的相对标准偏差(n=5)均小于2%。

Preparation and Application of a Potentiometric Sensor for Determination of Sibutramine Hydrochloride

By using the ion association complex formed between sibutramine hydrochloride and sodium tetraphenylborate as electroactive substance,and polyvinyl chloride(PVC) membrane as carrier,a potentiometric sensor was prepared,showing selective potential response toward sibutramine hydrochloride in the range of 1.0×10-6-1.0×10-1mol·L-1 with detection limit(3S/N) of 5.62×10-7mol·L-1,and slope of 50 mV·pc-1 in a solution of pH 5 at 26 ℃.Recovery of the method was tested by standard addition method on the base of samples of sibutramine hydrochloride drug,results of recovery found were in the range of 97.3%-100.2% with RSD′s(n=5) less than 2%.