| A FACTOR FROM GRANULOSA CELLS CAN STIMULATE OOCYTE TISSUE PLASMINOGEN ACTIVATOR ACTIVITY |
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| 作者姓名： | 刘以训 |
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| 作者单位： | Laboratory of |
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| 基金项目： | This work was supported by the Rockefeller Foundation, National Institutes of Health Research Grant and National Natural Science Foundation of China. |
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| 摘 要： | Several studies indicate that substances synthesized by granulosa cells are capableof regulating oocyte activity. We have studied the effect of factors synthesized by gran-ulosa cells on tPA activity of denuded oocytes using a co- culture system. The resultsshow that an FSH- dependent factor(s) synthesized by granulosa cells (but not by theca-interstitial cells) is capable of stimulating tPA activity of denuded oocytes. This findingis important for understanding hormonal regulation of oocyte tPA activity by mediatorssynthesized in granulosa cells.
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A FACTOR FROM GRANULOSA CELLS CAN STIMULATE OOCYTE TISSUE PLASMINOGEN ACTIVATOR ACTIVITY |
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| LIU YI-XUN Laboratory of Reproductive Biology.A FACTOR FROM GRANULOSA CELLS CAN STIMULATE OOCYTE TISSUE PLASMINOGEN ACTIVATOR ACTIVITY[J].Science in China(Chemistry),1989(12). |
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| Authors: | LIU YI-XUN Laboratory of Reproductive Biology |
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| Institution: | LIU YI-XUN Laboratory of Reproductive Biology,Institute of Zoology,Academia Sinica,Beijing 100080,PRC |
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| Abstract: | Several studies indicate that substances synthesized by granulosa cells are capable
of regulating oocyte activity. We have studied the effect of factors synthesized by gran-
ulosa cells on tPA activity of denuded oocytes using a co- culture system. The results
show that an FSH- dependent factor(s) synthesized by granulosa cells (but not by theca-
interstitial cells) is capable of stimulating tPA activity of denuded oocytes. This finding
is important for understanding hormonal regulation of oocyte tPA activity by mediators
synthesized in granulosa cells. |
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| Keywords: | granulosa cell secretory factor oocyte tissue plasminogen activator (tPA) |
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