| 5-羟基-3,4-二氢异喹啉-1-酮的合成 |
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| 引用本文： | 任眉,张睿,徐云根,华维一.5-羟基-3,4-二氢异喹啉-1-酮的合成[J].合成化学,2006,14(5):532-533. |
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| 作者姓名： | 任眉 张睿 徐云根 华维一 |
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| 作者单位： | 中国药科大学,新药研究中心,江苏,南京,210009;中国药科大学,新药研究中心,江苏,南京,210009;中国药科大学,新药研究中心,江苏,南京,210009;中国药科大学,新药研究中心,江苏,南京,210009 |
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| 摘 要： | 以异喹啉为起始原料,经成盐、磺化得异喹啉-5-磺酸(3),3与熔融的氢氧化钠和氢氧化钾反应得1,5-二羟基异喹啉(4),以5%Pd-C为催化剂还原4得5-羟基-3,4-二氢异喹啉-1-酮(1),总收率47.6%。1的结构经1H NMR和MS确证。
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| 关 键 词： | 异喹啉 喹啉酮 还原反应 合成 |
| 文章编号： | 1005-1511（2006）05-0532-02 |
| 收稿时间： | 2005-10-26 |
| 修稿时间： | 2005年10月26 |
Synthesis of 3,4-Dihydro-5-hydroxy-1(2H)-isoquinolinone |
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| REN Mei,ZHANG Rui,XU Yun-geng,HUA Wei-yi.Synthesis of 3,4-Dihydro-5-hydroxy-1(2H)-isoquinolinone[J].Chinese Journal of Synthetic Chemistry,2006,14(5):532-533. |
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| Authors: | REN Mei ZHANG Rui XU Yun-geng HUA Wei-yi |
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| Institution: | Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | 3,4-Dihydro-5-hydroxy-1(2H)-isoquinolinone(1) was synthesized from isoquinoline(2) by a three-step reaction that isoquinoline5-sulfonic acid(3) was prepared by the reaction of fuming sulfuric acid with 2,1,5-dihydroxy-isoquinoline(4) was obtained from 3 in a melted mixture of sodium hydroxide and potassium hydroxide and hydrogenation of 4 to 1 was fulfilled in the presence of 5% PdC.The overall yield of 1 was 47.6%.The structure of 1 was identified by ~1H NMR and MS. |
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| Keywords: | isoquinoline isoquinolinone reducing reaction synthesis |
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