Highly regioselective hydrogenolysis of bis(alpha-methylbenzyl)amine derivatives affected by the trifluoromethyl substituent on the aromatic ring |
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| Authors: | Kanai Masatomi Yasumoto Manabu Kuriyama Yokusu Inomiya Kenjin Katsuhara Yutaka Higashiyama Kimio Ishii Akihiro |
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| Institution: | Chemical Research Center, Central Glass Co., Ltd., Kawagoe, Saitama 350-1151, Japan. mkanai@cgco.co.jp |
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| Abstract: | reaction: see text] The highly regioselective hydrogenolysis of bis(alpha-methylbenzyl)amine derivatives proceeded with influence not from the electronic effect but from the steric effect of the trifluoromethyl substituent on the aromatic ring to provide a practical asymmetric synthesis of trifluoromethyl-substituted alpha-phenylethylamines. |
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