Short and diverse route toward complex natural product-like macrocycles |
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Authors: | Beck Barbara Larbig Gregor Mejat Beatrice Magnin-Lachaux Marina Picard Anne Herdtweck Eberhardt Dömling Alexander |
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Institution: | Morphochem AG, Gmunderstr. 37-37a, 81379 München, Germany. |
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Abstract: | reaction: see text] A general strategy toward macrocyclic compounds using multicomponent reaction (MCR) chemistry, e.g., Passerini and Ugi variants, and ring-closing metathesis (RCM) is introduced. The corresponding bifunctional isocyanides carboxylic acids bearing a terminal olefin are easy to prepare from the corresponding commercially available starting materials. Advantageously, this strategy allows fast access to a diverse conformational space of natural product-like macrocycles and could thus be of interest in the discovery of novel bioactive agents. |
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