Selective detection of fluorophore layers in turbid media: the role of fiber-optic probe design |
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Authors: | Pfefer T Joshua Matchette L Stephanie Ross Amanda M Ediger Marwood N |
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Affiliation: | Center for Devices and Radiological Health, Food and Drug Administration, 12725 Twinbrook Parkway, Rockville, Maryland 20857, USA. josh@eob.cdrh.fda.gov |
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Abstract: | Experimental verification of the ability to alter the sensitivity to fluorophore layers in turbid media by varying illumination-collection geometry is presented. Fiber-optic probes and two-layer, fluorophore-doped, turbid phantoms are used to elucidate the roles of spot size, illumination-collection fiber separation, and probe-sample spacing. Variations in single- and multiple-fiber probe design parameters produce significant changes in the relative sensitivity to sample layers in a manner that agrees with prior computational studies. |
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