The Interaction of Piroxicam with Neutral (HP-β-CD) and Anionically Charged (SBE-β-CD) β-cyclodextrin |
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| Authors: | YEHONG ZHOU GUOMEI ZHANG ZHONGRU WANG HAIYAN WANG CHUAN DONG SHAOMIN SHUANG |
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| Affiliation: | (1) Institute of Advanced Chemistry, College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, 030006, P.R. China |
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| Abstract: | The interaction of piroxicam (PX) with sulfobutylether-β-cyclodextrin (SBE-β-CD) was studied by fluorescence spectroscopy and compared with that of hydroxypropyl-β-cyclodextrin (HP-β-CD). The stability constants (K) values for the PX-CDs complexes were obtained by steady-state fluorescence measurements. Inclusion conditions including concentrations of the two cyclodextrins and pH values were investigated for the complex formation in detail. The results suggested that the interaction of PX with charged CD (SBE-β-CD) is much stronger than that with uncharged CD (HP-β-CD) at any pH studied, in terms of a synergetic effect of hydrophobic and additional electrostatic interactions. |
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| Keywords: | cyclodextrins piroxicam fluorescence inclusion complexes |
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