| Synthesis,Crystal Structure and Antiproliferative Activity of Ethyl 1-（Phenylcarbamoyl）-2-3,4,5-trimethoxyphenyl）cyclopropanecarboxylae |
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| 引用本文： | 张敬一,钟涵宇,史国兵. Synthesis,Crystal Structure and Antiproliferative Activity of Ethyl 1-（Phenylcarbamoyl）-2-3,4,5-trimethoxyphenyl）cyclopropanecarboxylae[J]. 结构化学, 2014, 33(6): 75-79 |
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| 作者姓名： | 张敬一 钟涵宇 史国兵 |
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| 作者单位： | [1]Department of Pharmacy, General Hospital ofShenyang Military Command, Shenyang 110016, China; [2]Department of Pharmacy, First Affiliated HospitalChina Medical University, Shenyang 110001, China |
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| 摘 要： | Many small-molecule compounds have been evaluated with potential antiproliferative activities. Ethyl 1-(phenylcarbamoyl)-2-(3,4,5-trimethoxyphenyl)cyclopropanecarboxylate, one novel cyclopropylamide analogue of combretastatin-A4(CA-4), has been synthesized and its crystal structure was characterized by X-ray single-crystal diffraction. The crystal belongs to monoclinic, space group P21/n, with a = 15.0263(3), b = 7.6574(2), c = 19.4117(4), β = 111.9010(10)o, V = 2072.36(8)3, Z = 4, C22H24NO6, Mr = 398.42, Dc = 1.277 Mg/cm3, F(000) = 844, λ(MoKα) = 1.54178 , μ = 0.770 mm–1, R = 0.0546 and wR = 0.1889 for 3319 observed reflections(I 2σ(I)). Meanwhile, the compound revealed potential antiproliferative activities in several cancer cells in vitro.
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| 关 键 词： | 增殖活性 晶体结构 甲酰基 三甲氧基 合成 小分子化合物 X射线单晶衍射 甲氧基苯基 |
Synthesis,Crystal Structure and Antiproliferative Activity of Ethyl 1-(Phenylcarbamoyl)-2-3,4,5-trimethoxyphenyl)cyclopropanecarboxylae |
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| ZHANG Jing-Yi , ZHONG Han-Yu , SHI Guo-Bing. Synthesis,Crystal Structure and Antiproliferative Activity of Ethyl 1-(Phenylcarbamoyl)-2-3,4,5-trimethoxyphenyl)cyclopropanecarboxylae[J]. Chinese Journal of Structural Chemistry, 2014, 33(6): 75-79 |
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| Authors: | ZHANG Jing-Yi ZHONG Han-Yu SHI Guo-Bing |
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| Affiliation: | 1. Department of Pharmacy, General Hospital of Shenyang Military Command, Shenyang 110016, China
2. Department of Pharmacy, First Affiliated Hospital,China Medical University, Shenyang 110001, China |
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| Abstract: | 3,4,5-trimethoxyphenyl,synthesis,crystal structure,antiproliferative activities |
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| Keywords: | -trimethoxyphenyl synthesis crystal structure antiproliferative activities |
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