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Optical resolution of new quinolone drugs by capillary electrophoresis with ligand-exchange and host-guest interactions
Authors:Takatomo Horimai  Motomu Ohara  Mitsunori Ichinose
Institution:

Analytical Research Center, Production Technology Research Laboratories, Daiichi Pharmaceutical Co., Ltd, 1-16-13, Kitakasai Edogawa-ku, Tokyo 134, Japan

Abstract:A method for the optical resolution of new quinolone drugs (NQs) by capillary electrophoresis has been investigated. The NQs were adequately resolved using a γ-cyclodextrin (γ-CD)-Zn(II)-Image -phenylalanine (Image -Phe) solution as the running solution. The resolution depended on the components of the running solution and their concentrations. When Image -Phe was used instead of Image -Phe, inversion of the migration order of the enantiomers was observed. The resolution mechanism is considered to be due to a ligand-exchange interaction of the NQs with Zn(II) and Image -Phe, in combination with a host-guest interaction of those with γ-CD.
Keywords:Enantiomer separation  Buffer composition  Pharmaceutical analysis  Quinolones  Ofloxacin
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