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Multi-anode detection in electrospray ionization time-of-flight mass spectrometry |
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| Authors: | D. C. Barbacci D. H. Russell J. A. Schultz J. Holocek S. Ulrich W. Burton M. Van Stipdonk |
| Affiliation: | 1. Department of Chemistry, Texas A&M University, The Laboratory for Biological Mass Spectrometry, College Station, Texas, USA 2. IonWerks, Inc., Houston, Texas, USA |
| Abstract: | An electrospray ionization ion source coupled to a time-of-flight mass analyzer incorporating a multi-anode time-to-digital converter is described. High-speed data acquisition (kHz mass spectral acquisition) rates are achieved. The four-anode detector produces a significant increase in detection/counting efficiency over that for a single-anode detector. In this work a 2.5 times increase in detection efficiency is demonstrated. The multi-anode detector is also used as a diagnostic tool to optimize transmission of the ion optics. |
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