The first asymmetric total syntheses and determination of absolute configurations of xestodecalactones B and C |
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| Authors: | Liang Qiren Zhang Jiyong Quan Weiguo Sun Yongquan She Xuegong Pan Xinfu |
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| Institution: | Department of Chemistry, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P.R. China. |
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| Abstract: | The first efficient asymmetric total syntheses of xestodecalactones B and C have been accomplished in 10 steps with an overall yield of 22 and 20.2%, respectively. The key steps involve the utility of Evans oxazolidinone-mediated syn-aldol condensations to establish the C-9 configuration and the macrolide ring formation by intramolecular acylation. The absolute configurations of xestodecalactones B and C have been determined via these syntheses. |
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