| Determination of captopril in pharmaceutical preparation and biological fluids using two- and three-way chemometrics methods |
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| 引用本文： | Nahid Ghasemi Ali Niazi. Determination of captopril in pharmaceutical preparation and biological fluids using two- and three-way chemometrics methods[J]. 中国化学快报, 2007, 18(4): 427-430. DOI: 10.1016/j.cclet.2007.02.019 |
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| 作者姓名： | Nahid Ghasemi Ali Niazi |
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| 作者单位： | Department of Chemistry Faculty of Sciences，Azad University of Arak，Arak，Iran，Department of Chemistry，Faculty of Sciences，Azad University of Arak，Arak，Iran |
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| 摘 要： | Spectrophotometric method has been developed for the direct quantitative determination of captopril in pharmaceuticalpreparation and biological fluids(human plasma and urine)samples.The method was accomplished based on parallel factoranalysis(PARAFAC)and partial least squares(PLS).The study was carried out in the pH range from 2.0 to 12.8 and with aconcentration from 0.70 to 61.50 μg mL~(-1)of captopril.Multivariate calibration models such as PLS at various pH and PARAFACwere elaborated from ultraviolet spectra deconvolution and captopril determination.The best models for this system were obtainedwith PARAFAC and PLS at pH 2.0.The applications of the method for determination of real samples were evaluated by analysis ofcaptopril in pharmaceutical preparations and biological fluids with satisfactory results.The accuracy of the method,evaluatedthrough the RMSEP,was 0.5801 for captopril with best calibration curve by PARAFAC and 0.6168 for captopril with PLS at pH 2.0model.
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| 关 键 词： | 药物制剂 体液 卡托普利 药物含量测定 化学计量学 |
| 收稿时间： | 2006-12-18 |
Determination of captopril in pharmaceutical preparation and biological fluids using two- and three-way chemometrics methods |
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| Nahid Ghasemi,Ali Niazi. Determination of captopril in pharmaceutical preparation and biological fluids using two- and three-way chemometrics methods[J]. Chinese Chemical Letters, 2007, 18(4): 427-430. DOI: 10.1016/j.cclet.2007.02.019 |
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| Authors: | Nahid Ghasemi Ali Niazi |
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| Affiliation: | Department of Chemistry, Faculty of Sciences, Azad University of Arak, Arak, Iran |
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| Abstract: | Spectrophotometric method has been developed for the direct quantitative determination of captopril in pharmaceutical preparation and biological fluids (human plasma and urine) samples. The method was accomplished based on parallel factor analysis (PARAFAC) and partial least squares (PLS). The study was carried out in the pH range from 2.0 to 12.8 and with a concentration from 0.70 to 61.50 μg mL−1 of captopril. Multivariate calibration models such as PLS at various pH and PARAFAC were elaborated from ultraviolet spectra deconvolution and captopril determination. The best models for this system were obtained with PARAFAC and PLS at pH 2.0. The applications of the method for determination of real samples were evaluated by analysis of captopril in pharmaceutical preparations and biological fluids with satisfactory results. The accuracy of the method, evaluated through the RMSEP, was 0.5801 for captopril with best calibration curve by PARAFAC and 0.6168 for captopril with PLS at pH 2.0 model. |
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| Keywords: | Captopril Spectrophotometric Parallel factor analysis Partial least squares Pharmaceutical analysis |
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