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Determination of ephedrine and codeine in human urine by cation-selective exhaustive injection and sweeping micellar electrokinetic chromatography |
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| Authors: | Li Jun Li Si Guang Lib Hai Yan Lic Zhuo Caib Hao Chenga a |
| Affiliation: | a Department of Biological and Chemical Engineering, Guangxi University of Technology, Liuzhou 545006, China;b College of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China;c Zhongshan School of Medicine, Sun-Yat-Sen University, Guangzhou 510080, China |
| Abstract: | A sensitive method for the determination of ephedrine and codeine in human urine by capillary electrophoresis (CE) was described. In order to improve the sensitivity, two online concentration techniques including cation-selective exhaustive injection (CSEI) and sweeping micellar electrokinetic chromatography (sweeping-MEKC) were used. Under the optimum conditions, the detection limits (S/N = 3) were 0.10 μg/L for ephedrine and 0.80 μg/L for codeine. This method was successfully applied to real urine sample analysis. |
| Keywords: | Cation-selective exhaustive injection Sweeping mieellar eleetrokinetie chromatography Ephedrine Codeine |
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