Preparation of [Arg-Gly-Asp]-[amino-poly(ethylene glycol)] hybrids and their inhibitory effect on experimental metastasis. |
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| Authors: | K Kawasaki M Namikawa Y Yamashiro T Hama T Mayumi |
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| Institution: | Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Japan. |
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| Abstract: | Hybrids of a fibronectin-related tripeptide (Arg-Gly-Asp) and amino-poly(ethylene glycol) were prepared and their inhibitory effect on experimental metastasis in mice was examined. The hybrids exhibited a potent inhibitory effect on the metastasis of B16 melanoma BL6. |
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