Copper(I)-Fesulphos Lewis Acid catalysts for enantioselective Mannich-type reaction of N-sulfonyl imines |
| |
Authors: | Gonzalez Alvaro Salvador Arrayas Ramón Gómez Carretero Juan C |
| |
Institution: | Departamento de Química Organica, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, Spain. |
| |
Abstract: | reaction: see text] Copper(I) complexes of Fesulphos ligands are efficient chiral Lewis acid catalysts in the Mannich-type addition of silyl enol ethers of ketones, esters, and thioesters to N-(2-thienyl)sulfonyl aldimines. The corresponding optically active beta-amino carbonyl derivatives were obtained in good yields (58-91%) and with moderate to good enantioselectivity (61-93% ee). Removal of the N-activating group was achieved under mild conditions by simple treatment of the products with Mg in methanol. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|