1,n-Diamines. Part 4: synthesis of 1-aryl-2-alkyl-1,4,5,6,7,8-hexahydro-1,3-diazocines |
| |
Authors: | Jimena E DíazNadia Gruber Liliana R Orelli |
| |
Institution: | Departamento de Química Orgánica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, CONICET, Junín 956, (1113) Buenos Aires, Argentina |
| |
Abstract: | In this Letter we present the synthesis of hitherto unreported 1-aryl-2-alkyl-1,4,5,6,7,8-hexahydro-1,3-diazocines 1. Cyclic amidines 1 were synthesized by PPSE promoted ring closure of N-acyl-N′-arylpentamethylenediamines 2. The cyclodehydration reaction was performed under microwave irradiation in solvent-free conditions. Precursors 2 were prepared by selective functionalization of N-arylcadaverines 3. |
| |
Keywords: | Polyamine analogs Cyclic amidines Medium size heterocycles PPSE Microwaves |
本文献已被 ScienceDirect 等数据库收录! |
|